0827 Effect of virtual cognitive behavioral therapy for insomnia on perceived cognitive functioning among cancer survivors

Abstract Introduction Comorbid insomnia and perceived cognitive impairments (PCI) affect up to 26% of individuals diagnosed with cancer. Given the association between sleep cognition, lack interventions improve PCI, present study examined impact behavioral therapy for (CBT-I) on PCI among cancer survivors disorder complaints (clinicaltrials.gov:NCT04026048). Methods Cancer (N=122) were randomized 7 weekly virtual CBT-I treatment sessions (n=56) or waitlist control (WLC: n=66). Participants completed Insomnia Severity Index Functional Assessment Therapy – Cognitive Function upon entering (baseline; T0), then again at 4 (T1), 8 (T2) weeks. A series 2 (treatment group: WLC) by 3 (time: T0, T1, T2) mixed ANOVAs performed assess changes in symptoms, abilities (PCA), function quality life (QOL). Results were, average, aged 60 years, had 16 years education, 79% female. Breast was most reported type (46%). No significant differences observed groups T0 demographic clinical variables (p>.05). There a group time interaction [p=<.001, partial eta squared (pes)=.36]. Individuals decreases symptoms post compared WLC (CBT-I: -11.5; WLC: -2.7). Significant interactions also (p=<.001, pes=.11), PCA pes=.16), QOL pes=.15). significantly less 14.7; 4.1), better 5.8; 1.1), 4.9; 1.1) than participants WLC. Conclusion In addition improving insomnia, functioning survivors. Further research is needed understand mechanisms underlying improvements cognition following CBT-I. Support (if any) Dr. Sheila Garland supported Canadian Society Emerging Scholar Award (Survivorship) (grant #707146). This project funded through grant from Institutes Health Research (CIHR) number: PJT 162428) Beatrice Hunter Institute.